The interest in peptides as potential drug candidates is currently very high and the production of chemically synthesised peptides (<20–30 amino acid residues) is now a routine laboratory procedure. The method can prepare quantities of peptides from a few mg up to several g. However, there are numerous ways in which the synthesis can go wrong, so that alternative peptides are produced together with the desired one. Such impurities may originate in a low coupling yield, giving rise to truncated and deleted sequences, or from incomplete removal of protective groups. Other impurities may originate from alteration of sensitive amino acids, e.g. oxidation or alkylation of methionine and tryptophan, ring formation by N-terminal glutamine, dehydration of asparagine or glutamine, and transamidation or deamidation of asparagine and glutamine. In addition, racemisation of the amino acids may occur during coupling. It is obvious that these potential impurities, frequently having quite similar chemical properties, sometimes offer great challenges when purifying the target peptide.
原文見PDF附件：
專肽生物提供多種淀粉樣肽（Amyloid Peptides），部分序列有現(xiàn)貨，其它序列可定制合成。產(chǎn)品鏈接：Amyloid Peptides
