This inhibitor of the human CMV assemblin protease is derived from RGVVNASSRLAK, the M-site substrate of the protease. RGVVNA-psi[CH2-NH]SSRLA contains a non-hydrolyzable reduced peptide bond at the cleavage site. Its IC?? value is high (> 500 µM) but it is the first peptidomimetic inhibitor designed for the human CMV protease. 

這種人巨細(xì)胞病毒組裝素蛋白酶抑制劑來源于該蛋白酶的m位點(diǎn)底物RGVVNASSRLAK。rgvna -psi[CH2-NH]SSRLA在裂解位點(diǎn)含有一個(gè)不可水解的還原肽鍵。它的IC?0值很高(> 500 μ M)，但它是第一個(gè)為人類CMV蛋白酶設(shè)計(jì)的擬肽抑制劑。