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溶酶體二肽 LLME 對 NK 細(xì)胞、CTL 和 Mphi 具有選擇性毒性，而對各種其他淋巴樣或非淋巴樣細(xì)胞類型沒有不利影響。
編號：200193
CAS號：16689-14-8
單字母：H2N-LL-OMe
| 編號: | 200193 |
| 中文名稱: | 二肽Leu-Leu-甲酯化 |
| CAS號: | 16689-14-8，HBr鹽 |
| 單字母: | H2N-LL-OMe |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽鏈中含有游離a-氨基的氨基酸一端。在表示氨基酸序列時，通常將N端放在肽鏈的左邊。 -LeuL-亮氨酸：leucine。系統(tǒng)命名為(2S)-氨基-4-甲基戊酸。是編碼氨基酸。是哺乳動物的必需氨基酸。符號：L，Leu。 -LeuL-亮氨酸：leucine。系統(tǒng)命名為(2S)-氨基-4-甲基戊酸。是編碼氨基酸。是哺乳動物的必需氨基酸。符號：L，Leu。 -OMeC端甲酯化修飾 |
| 氨基酸個數(shù): | 2 |
| 分子式: | C13H26N2O3 |
| 平均分子量: | 258.36 |
| 精確分子量: | 258.19 |
| 等電點(PI): | - |
| pH=7.0時的凈電荷數(shù): | 0.97 |
| 平均親水性: | -1.8 |
| 疏水性值: | 3.8 |
| 消光系數(shù): | - |
| 來源: | 人工化學(xué)合成，僅限科學(xué)研究使用，不得用于人體。 |
| 儲存條件: | 負(fù)80℃至負(fù)20℃ |
| 標(biāo)簽: | 二肽(Dipeptide) |
The lysosomotropic dipeptide LLME has selective toxicity for NK cells, CTL, and M phi without adverse effects on a variety of other lymphoid or nonlymphoid cell types.
| DOI | 名稱 | |
|---|---|---|
| 10.1074/jbc.M308347200 | Selective disruption of lysosomes in HeLa cells triggers apoptosis mediated by cleavage of Bid by multiple papain-like lysosomal cathepsins | 下載 |
| 10.1271/bbb.70.966 | Identification of genes involved in the suppression of antibody production from human peripheral blood lymphocytes | 下載 |
| 10.1271/bbb.60460 | Anti-peptide antibody production elicited by in vitro immunization of human peripheral blood mononuclear cells | 下載 |
| 10.1016/j.taap.2007.12.021 | A new lactoferrin- and iron-dependent lysosomal death pathway is induced by benzo[a]pyrene in hepatic epithelial cells | 下載 |
| 10.1271/bbb.80640 | Production of human monoclonal antibodies against Fc(epsilon)RI(alpha) by a method combining in vitro immunization with phage display | 下載 |
| 10.1271/bbb.100243 | Generation of a human anti-tumor necrosis factor-α monoclonal antibody by in vitro immunization with a multiple antigen peptide | 下載 |
| 10.1111/j.1365-3083.2011.02589.x | Lysosomal membrane permeabilization induces cell death in human mast cells | 下載 |
| 10.4049/jimmunol.1300216 | Active caspase-3 is stored within secretory compartments of viable mast cells | 下載 |
| 10.1007/s00109-015-1275-1 | Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage | 下載 |
| 10.1371/journal.pone.0165653 | P2Y1 Receptor Signaling Contributes to High Salt-Induced Priming of the NLRP3 Inflammasome in Retinal Pigment Epithelial Cells | 下載 |
| 10.1073/pnas.82.8.2468 | Regulation of cellular function by products of lysosomal enzyme activity: elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes | 下載 |
| 10.1021/tx300114x | Lysosomes as a possible target of enniatin B-induced toxicity in Caco-2 cells | 下載 |
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