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通過(guò)FPR樣受體（FPRL）2特異性發(fā)揮作用，從而促進(jìn)樹突狀細(xì)胞中鈣的動(dòng)員和趨化性。
編號(hào)：134328
CAS號(hào)：946571-77-3
單字母：Ac-MLGMIKNSLFGSVETWPWQVL-OH
F2L是對(duì)應(yīng)于人血紅素結(jié)合蛋白的N-末端片段的乙?；?。Ac MLGMIKNSLFGSVETWPWQVL通過(guò)FPR樣受體（FPRL）2特異性作用，促進(jìn)樹突狀細(xì)胞和單核細(xì)胞中的鈣動(dòng)員和趨化性。在中性粒細(xì)胞中，F(xiàn)2L抑制FPR和FPRL1介導(dǎo)的信號(hào)傳導(dǎo)。
F2L is an acetylated peptide corresponding to an N-terminal fragment of the human heme-binding protein. Ac-MLGMIKNSLFGSVETWPWQVL acts specifically through the FPR-like receptor (FPRL) 2 promoting calcium mobilization and chemotaxis in dendritic cells and monocytes. In neutrophils, F2L inhibited FPR and FPRL1-mediated signaling.
| DOI | 名稱 | |
|---|---|---|
| 10.1084/jem.20041277 | Identification and characterization of an endogenous chemotactic ligand specific for FPRL2 | 下載 |
| 10.1016/j.bbrc.2007.06.001 | F2L, a peptide derived from heme-binding protein, inhibits formyl peptide receptor-mediated signaling | 下載 |
| 10.1016/j.febslet.2007.12.015 | F2L, a peptide derived from heme-binding protein, inhibits LL-37-induced cell proliferation and tube formation in human umbilical vein endothelial cells | 下載 |
| 10.4049/jimmunol.1003545 | Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3 | 下載 |
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