Z-Phe-酪氨酸是一種有效的選擇性組織蛋白酶L抑制劑。在用未分級的大鼠骨細胞進行的凹坑形成測定中，1.5nM的Z-FY-CHO顯著抑制甲狀旁腺激素刺激的破骨細胞性骨吸收。在去卵巢的小鼠中，它以2.5-10 mg/kg/天的ip劑量依賴性地抑制四周的骨重量減輕。

Z-Phe-Tyrosinal is a potent and selective cathepsin L inhibitor. In the pit formation assay with unfractionated rat bone cells, 1.5 nM of Z-FY-CHO markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption. In ovariectomized mice, it suppressed at 2.5-10 mg/kg/day ip for four weeks bone weight loss dose-dependently.

組織蛋白酶L抑制劑是組織蛋白酶的強效抑制劑，其IC50為0.85 nM。它對布魯氏菌具有45nM的ED50值的錐蟲殺性，該ED50值遠低于人HL-60細胞21500nM的ED 50值。在體內(nèi)，組織蛋白酶L抑制劑（2.5-10 mg/kg）以劑量依賴性方式抑制骨質疏松小鼠模型中的骨丟失。組織蛋白酶L抑制劑還可以完全抑制從牛皮質骨分離的股骨切片上破骨細胞凹坑的形成。

Cathepsin L inhibitor is a potent inhibitor of cathepsin L with IC50 of 0.85 nM. It is trypanocidal with an ED50 value of 45 nM against T. brucei that is well below the ED50 value of 21,500 nM for human HL-60 cells. In vivo, cathepsin L inhibitor (2.5-10 mg/kg) inhibits bone loss in a mouse model of osteoporosis in a dose-dependent manner. Cathepsin L inhibitor can also completely suppress osteoclastic pit formation on femur slices isolated from bovine cortical bone.