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細(xì)胞可滲透的、不可逆的 caspase-1 (ICE) 抑制劑。N.Rouquet 等。表明Ac-YVAD-CMK是一種有效的治療小鼠體內(nèi)肝細(xì)胞凋亡的藥物。
編號(hào)：169055
CAS號(hào)：178603-78-6
單字母：Ac-YVAD-CMK
| 編號(hào): | 169055 |
| 中文名稱: | Caspase 1 Inhibitor II |
| 英文名: | Caspase 1 Inhibitor II |
| CAS號(hào): | 178603-78-6 |
| 單字母: | Ac-YVAD-CMK |
| 三字母: | Ac N端乙?；舛?/p> -TyrL-酪氨酸：tyrosine。系統(tǒng)命名為(2S)-氨基-3-(4-羥基苯基)丙酸。是編碼氨基酸。符號(hào)：Y，Tyr。 -ValL-纈氨酸：valine。系統(tǒng)命名為(2S)-氨基-3-甲基丁酸。是編碼氨基酸。是哺乳動(dòng)物的必需氨基酸。符號(hào)：V，Val。在某些放線菌素如纈霉素中存在 D-纈氨酸。 -Ala丙氨酸：alanine。L-丙氨酸的系統(tǒng)命名為(2S)-氨基丙酸，是編碼氨基酸，也叫L-α-丙氨酸。符號(hào)：A，Ala。D-丙氨酸存在于多種細(xì)菌細(xì)胞壁的糖肽中。β-丙氨酸是維生素泛酸和輔酶A的組分。 -AspL-天冬氨酸：aspartic acid。系統(tǒng)命名為(2S)-氨基-丁二酸。是編碼氨基酸，又是神經(jīng)遞質(zhì)。符號(hào)：D，Asp。D-天冬氨酸存在于多種細(xì)菌的細(xì)胞壁和短桿菌肽A中。 -CMKC端氯甲基酮修飾 |
| 氨基酸個(gè)數(shù): | 4 |
| 分子式: | C24H33O8N4Cl1 |
| 平均分子量: | 540.99 |
| 精確分子量: | 540.2 |
| 等電點(diǎn)(PI): | 7.01 |
| pH=7.0時(shí)的凈電荷數(shù): | - |
| 平均親水性: | -0.6 |
| 疏水性值: | 0.4 |
| 外觀與性狀: | 白色粉末狀固體 |
| 消光系數(shù): | 1490 |
| 來(lái)源: | 人工化學(xué)合成，僅限科學(xué)研究使用，不得用于人體。 |
| 純度: | 95%、98% |
| 鹽體系: | 可選TFA、HAc、HCl或其它 |
| 儲(chǔ)存條件: | 負(fù)80℃至負(fù)20℃ |
| 標(biāo)簽: | CMK(氯甲基酮)修飾 |
Cell-permeable, irreversible inhibitor of caspase-1 (ICE). N.Rouquet et al. showed that Ac-YVAD-CMK is a potent therapeutic agent against in vivo liver apoptosis in mice.
| DOI | 名稱 | |
|---|---|---|
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| 10.1038/sj.bjp.0703629 | Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses | 下載 |
| 10.1107/s0907444900009884 | Crystallization and preliminary X-ray diffraction analysis of a recombinant cysteine-free mutant of crmA | 下載 |
| 10.1111/j.1349-7006.2003.tb01358.x | Evodiamine, a constituent of Evodiae Fructus, induces anti-proliferating effects in tumor cells | 下載 |
| 10.1038/sj.cdd.4401247 | Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity | 下載 |
| 10.1254/jphs.fpj03102x | Dracorhodin perchlorate induces apoptosis via activation of caspases and generation of reactive oxygen species | 下載 |
| 10.1248/bpb.27.1527 | Oridonin induces a caspase-independent but mitochondria- and MAPK-dependent cell death in the murine fibrosarcoma cell line L929 | 下載 |
| 10.1080/09674845.2004.11732672 | Induction of apoptosis in myeloid progenitors by granulocyte-macrophage colony-stimulating factor | 下載 |
| 10.1016/j.cell.2006.07.033 | Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival | 下載 |
| 10.1016/j.surneu.2007.03.041 | Neuroprotective effects of Ac.YVAD.cmk on experimental spinal cord injury in rats | 下載 |
| 10.1016/j.cellbi.2008.08.021 | Cadmium toxicity in cultured tomato cells--role of ethylene, proteases and oxidative stress in cell death signaling | 下載 |
| 10.1002/eji.201142268 | IL-18 associates to microvesicles shed from human macrophages by a LPS/TLR-4 independent mechanism in response to P2X receptor stimulation | 下載 |
| 10.1016/j.brainres.2014.04.019 | Chemical stimulation of the intracranial dura activates NALP3 inflammasome in trigeminal ganglia neurons | 下載 |
| 10.1371/journal.ppat.1004599 | Uropathogenic Escherichia coli superinfection enhances the severity of mouse bladder infection | 下載 |
| 10.1046/j.1365-2567.2000.00921.x | CD95 ligand expression as a mechanism of immune escape in breast cancer | 下載 |
| 10.1046/j.1462-5822.2001.00162.x | Salmonella pathogenicity island 2-dependent macrophage death is mediated in part by the host cysteine protease caspase-1 | 下載 |
| 10.1248/bpb.26.1543 | Intracellular regulation of evodiamine-induced A375-S2 cell death | 下載 |
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