DOI: 10.1038/ncomms2071
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動物生活環(huán)境與動物基因表達之間的關(guān)系是生命科學研究的中心議題之一。其中食物是動物環(huán)境的重要組成部分。單革教授實驗室的研究表明，大腸桿菌（Escherichia coli）可以利用其自身產(chǎn)生的非編碼RNA來調(diào)控取食它的秀麗線蟲（Caenorhabditis elegans）的基因表達和生理功能。非編碼RNA作為一類不編碼蛋白質(zhì)的核糖核酸分子，是目前生命科學研究的熱點之一。此研究顯示非編碼RNA可以具有物種間的調(diào)控作用，并且暗示非編碼RNA可能參與了物種之間相互關(guān)系形成的進化過程。這一研究對進一步認識非編碼RNA的功能及功能機理具有一定的啟示意義。
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Abstract: Food and other environmental factors affect gene expression and behavior of animals. Differences in bacterial food affect the behavior and longevity of C. elegans. However, no research has been carried out to investigate whether bacteria could utilize endogenous RNAs to affect C. elegans physiology. Here we show that two E. coli endogenous noncoding RNAs, OxyS and DsrA, impact on the physiology of C. elegans. OxyS downregulates che-2, leading to impairment in C. elegans chemosensory behaviour and DsrA suppresses diacylglycerol lipase gene F42G9.6, leading to a decrease in longevity. We also examine some genes in the C. elegans RNA interference pathway for their possible involvement in the effects of OxyS and DsrA. Other bacteria, such as Bacillus mycoides, may also utilize its noncoding RNAs to interfere with gene expression in C. elegans. Our results demonstrate that E. coli noncoding RNAs can regulate gene expression and physiological conditions of C. elegans and indicate that noncoding RNAs might have interspecies ecological roles.
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