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2013.10.26，我院溫龍平教授研究組與印度化學(xué)技術(shù)研究所（CSIR-IICT）合作在Biomaterials上在線發(fā)表題為“Accelerating the clearance of mutant huntingtin protein aggregates through autophagy induction by europium hydroxide nanorods”的論文
作者：魏鵬飛、張力、Susheel Kumar Nethi、Ayan Kumar Barui、林俊、周偉、沈藝、滿娜、張?jiān)茓伞⒃S靜、Chitta Ranjan Patra*和溫龍平*
Abstract
Autophagy is one of the well-known pathways to accelerate the clearance of protein aggregates, which contributes to the therapy of neurodegenerative diseases. Although there are numerous reports that demonstrate the induction of autophagy with small molecules including rapamycin, trehalose and lithium, however, there are few reports mentioning the clearance of aggregate-prone proteins through autophagy induction by nanoparticles. In the present article, we have demonstrated that europium hydroxide [EuIII(OH)3] nanorods can reduce huntingtin protein aggregation (EGFP-tagged huntingtin protein with 74 polyQ repeats), responsible for neurodegenerative diseases. Again, we have found that these nanorods induce authentic autophagy flux in different cell lines (Neuro 2a, PC12 and HeLa cells) through the expression of higher levels of characteristic autophagy marker protein LC3-II and degradation of selective autophagy substrate/cargo receptor p62/SQSTM1. Furthermore, depression of protein aggregation clearance through the autophagy blockade has also been observed by using specific inhibitors (wortmannin and chloroquine), indicating that autophagy is involved in the degradation of huntingtin protein aggregation. Since [EuIII(OH)3] nanorods can enhance the degradation of huntingtin protein aggregation via autophagy induction, we strongly believe that these nanorods would be useful for the development of therapeutic treatment strategies for various neurodegenerative diseases in near future using nanomedicine approach.
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http://dx.doi.org/10.1016/j.biomaterials.2013.10.024
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