題? 目： New approach of dendrimer and dendrimer like MRI contrast agents. Synthesis and relaxivity
報告人：István Bányai 教授
??? Debrecen University
時? 間：2019年6月18日（星期二）9:30
地? 點：四號學(xué)院樓3083 室
主持人：史向陽 教授
?報告人簡介：
??? DIstván Bányai, Professor, Department of Physical Chemistry，University of Debrecen, Faculty of Science and Technology. In 1993 and 1998 he was visiting professor at The Royal Institute of Technology of Sweden. In 2003 he was invited as senior researcher to the University of Michigan doing NMR on PAMAM dendrimers. In 2006 he gained the chair of the Department of Colloid and Environmental Chemistry at the same university. The number of his officially registered publications is 99. According to the Thomson and Reuters he has received more than 1500 citations and his Hirsch index is 27.
?報告內(nèi)容簡介：
? ? Paramagnetic complexes of Gd(III) and Mn(II) are of great importance as MRI contrast agents. The basic requirements are high relaxivity and labile water molecules in the first coordination sphere. High thermodynamic and kinetic stability are also vital to prevent the toxicity of the free metal ions. We show a new approach to this problem from the basic research side. Organic nanoparticles were prepared containing the important -N[(CH2COOH)2] units in size of about 8 nm on polyethylene-imine and G5_PAMAM dendrimer platforms. These nanoparticles were used as ligands for both Gd(III) and Mn(II) ions. We found that the very important feature of the prepared complexes is that neither of them contain water molecules directly coordinating to the metal ions at physiological pH in spite of their high relaxivity. This means that the risk of coordination of proteins to the metal ions in these complexes, thus the toxicity and the decomposition are much less probable. ?
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