報告題目：Targeting the fungal cell wall
報告人：Daan Van Aalten教授，英國鄧迪大學(xué)生命科學(xué)學(xué)院生物化學(xué)教授，蘇格蘭皇家學(xué)會院士， ? ??
? ? ? ? ?Wellcome Trust高級研究員
時間：2015年4月23日上午10:00
地點：生科院三樓圓形會議室
舉辦單位：江蘇省功能與微生物基因組學(xué)重點實驗室
歡迎參加交流！
Daan Van Aalten教授簡介：
? ? 英國鄧迪大學(xué)生命科學(xué)學(xué)院生物化學(xué)教授，蘇格蘭皇家學(xué)會院士，Wellcome Trust高級研究員。Daan 教
授致力于蛋白后修飾研究，尤其是在細(xì)胞壁蛋白糖基化研究方面成果卓著。
University education?
09-1989/01-1994: BSc Chemistry, University of Nijmegen, The Netherlands.?
02-1994/01-1997: PhD in Biochemistry/Biophysics. Prof. John Findlay, Leeds, U.K. ?
Professional history?
02-1997/03-1999: Postdoc in the lab of Dr. Leemor Joshua-Tor at Cold Spring Harbor?
Laboratory,?
funded by an EMBO Long-term Fellowship.?
05-1999/10-1999: Postdoc in the lab of Prof. Rik Wierenga, Oulu University, Finland.?
Lecturer (1999), Reader (2002) and Professor of Biological Chemistry (2006 - present) in?
the Division of Biological Chemistry & Drug Discovery (1999 – 2009), the Division of?
Molecular Microbiology (2009 – present) and the MRC Protein Phosphorylation and?
Ubiquitylation Unit (2012 – present), College of Life Sciences, University of Dundee,?
Scotland.
Research?
Carbohydrates are essential building blocks of polysaccharide structures and glycans on the?
microbial and human cell. Interactions of these carbohydrates with proteins that?
synthesize, recognise or modify them are essential steps in a wide range of processes such?
as microbial cell wall synthesis/recognition, cell signalling pathways and the human immune?
system. ?I am interested in studying the structural aspects and mechanism of protein-
carbohydrate interactions, and applies the knowledge gained from these approaches to design?
molecules that modulate these interactions in biological systems and have applications as?
research tools or leads for the development of chemotherapeuticals. We use a?
multidisciplinary approach, involving X-ray crystallography, enzymology, mutagenesis,?
affinity measurements, high-throughput screening and novel computational techniques.?
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