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報告題目：O-GlcNAc nutrient sensor mediates muscle-fat crosstalk.

報告人： Shi, Hao（時浩）助理教授 ?弗吉尼亞理工大學(xué) ?

時間：2016年1月5日（周二）上午10點

地點：生科院三樓圓形會議室

Hao Shi簡介

姓名： Shi, Hao（時浩）

工作單位：弗吉尼亞理工大學(xué) ?動物科學(xué)系

1993-1996 ?南京農(nóng)業(yè)大學(xué) 動物醫(yī)學(xué)院 動物生理學(xué)與生物化學(xué) 碩士?

2002-2007 ?Purdue University 動物科學(xué)系 肌肉生物學(xué) ?博士

2007-2010 ?Yele University 醫(yī)學(xué)院 藥理學(xué)系 肌肉代謝生物學(xué) ?博士后

1996-1998 ?復(fù)旦大學(xué)醫(yī)學(xué)中心 比較醫(yī)學(xué)系 講師

1999-2000 ?復(fù)旦大學(xué)醫(yī)學(xué)中心 比較醫(yī)學(xué)系 ?助理教授

2010-2012 ?Yele University 醫(yī)學(xué)院 藥理學(xué)系A(chǔ)ssociate Research Scientist

2013-至今 ?Virginia Polytechnic Institute and State University 動物科學(xué)系 助理教授

發(fā)表的代表性論文
1.?? ?Shi, H., H.W. Geisler, S. Li, Z. Zhen, E. England, R.F. Helm, J. Wu, X. Yang, and D.E. Gerrard. O-GlcNAc transferase is required for the maintenance of skeletal muscle and systemic metabolic homeostasis. Cell Metabolism 2016; Revised.?
2.?? ?Shi, H., F. Gatzke, J. M. Molle, H. B. Lee, E. T. Helm, J. J. Oldham, L. Zhang, D. E. Gerrard and A. M. Bennett. Mice lacking MKP-1 and MKP-5 reveal hierarchical regulation of regenerative myogenesis. ?Journal of Stem Cell and Regenerative Medicine 2015; 1: 1-7.?
3.?? ?Shi, H., M. Verma, L. Zhang, C. Dong, R.A. Flavell, and A. M. Bennett. Improved regenerative myogenesis and muscular dystrophy in mice lacking Mkp5. The Journal of Clinical Investigation 2013;123:2064-2077.
4.?? ?Shi, H., E. Boadu, F. Mercan, L. Zhang, A.M. Le, R.J. Roth Flach, K.J. Tyner, B.B. Olwin, and A.M. Bennett. MAP kinase phosphatase-1 deficiency impairs skeletal muscle regeneration and exacerbates muscular dystrophy. The FASEB J 2010;24:2985-2997.
5.?? ?Shi, H., J.M. Scheffler, J.M. Pleitner, C. Zeng, S. Park, K.M. Hannon, A.L. ?Grant, and D.E. Gerrard. ?Modulation of skeletal muscle fiber type by mitogen-activated protein kinase signaling. The FASEB Journal 2008;22:2990-3000.
6.?? ?Shi, H., J.M. Scheffler, J.M. Pleitner, C. Zeng, S. Park, K.M. Hannon, A.L. Grant, and D.E. Gerrard. Mitogen-activated protein kinase is necessary for the maintenance of skeletal muscle mass. ?American Journal of physiology Cell Physiology 2009;296: C1040-1048.
7.?? ?Shi, H., C. Zeng, A. Ricome, K.M. Hannon, A.L. Grant, and D.E. Gerrard ?. Extracellular signal-regulated kinase pathway is differentially involved in β-agonist-induced hypertrophy in slow and fast muscles. American Journal of Physiology Cell Physiology 2007;292:C1681-1689.