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Magnetofluorescent Fe3O4/carbon quantum dots coated single-walled carbon nanotubes as dual-modal targeted imaging and chemo/photodynamic/photothermal triple-modal therapeutic agents

Zhang, M (Zhang, Ming)[ 1,3 ] ; Wang, WT (Wang, Wentao)[ 2 ] ; Cui, YJ (Cui, Yingjun)[ 3 ] ; Chu, XH (Chu, Xiaohong)[ 1 ] ; Sun, BH (Sun, Baohong)[ 1 ] ; Zhou, NL (Zhou, Ninglin)[ 1,4 ]*（周寧琳）; Shen, J (Shen, Jian)[ 1 ]*（沈健）

[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Jiangsu, Peoples R China

[ 2 ] Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Mol & Med Biotechnol, Nanjing 210023, Jiangsu, Peoples R China

[ 3 ] Florida Int Univ, Dept Biol Sci, Miami, FL 33199 USA

[ 4 ] Nanjing Zhou Ninglin Adv Mat Technol Co Ltd, Nanjing 211505, Jiangsu, Peoples R China

CHEMICAL ENGINEERING JOURNAL，201804,338,526-538

In this work, PEG 2000N modified Fe3O4@carbon quantum dots (CQDs) coated single-walled carbon nanotubes (SWNTs) are fabricated and utilized as a multifunctional platform for imaging-guided collaborative treatment of cancer when the obtained agents act as dual photodynamic and photothermal effect under 808 nm laser irradiation. A model chemotherapy drug, doxorubicin (DOX), could be loaded into the pore structure of the obtained SWCNTs-PEG-Fe3O4@CQDs nano-carriers with high efficiency. These magnetofluorescent SWCNTs-PEGFe(3)O(4)@ CQDs were conjugated with a sgc8c aptamer, denoted as SWCNTs-PEG-Fe3O4@CQDs-DOX-Apt, for targeting dual modalfluorescence/magnetic resonance (MR) imaging. Multifunctional SWCNTs-PEGFe(3)O(4)@CQDs-DOX-Apt had a strong effect on the targeted lung cancer cells, in the manner of inducing photodynamic and photothermal ablation, and was found to release DOX rapid following irradiation with pH/NIR laser. The current research demonstrates that SWCNTs-PEG-Fe3O4@CQDs-DOX-Apt nanocomposites can be used as an efficient nanoplatform for combing cancer photothermal therapy (PTT), photodynamic therapy (PDT) and chemotherapy (CT).

文章鏈接：

https://www.sciencedirect.com/science/article/pii/S1385894718300974?via%3Dihub