戴志暉教授課題組在 SENSORS AND ACTUATORS B-CHEMICAL發(fā)表研究論文
Fabrication of non-destructive and enhanced electrochemiluminescence interface for reusable detection of cell-released dopamine
Wang, ZY (Wang, Zhaoyin)[ 1,2 ] ; Wang, XY (Wang, Xiaoying)[ 1,2 ] ; Zhu, XS (Zhu, Xiaoshu)[ 3 ] ; Lv, JL (Lv, Jianlin)[ 1,2 ] ; Zhang, J (Zhang, Jia)[ 1,2 ] ; Zhu, QS (Zhu, Qinshu)[ 3 ]*; Dai, ZH (Dai, Zhihui)[ 1,2,3 ]*（戴志暉）
[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 3 ] Nanjing Normal Univ Ctr Anal & Testing, Nanjing 210023, Jiangsu, Peoples R China
SENSORS AND ACTUATORS B-CHEMICAL，201904,285,438-444
Quantification of cell-released dopamine (DA) is essential to understand various biological processes. However, concentration of DA outside living cells may increase and decrease in a short time. Thus, approaches used to detect cell-released DA should meet higher demands. Herein, a simple and green method is employed to in situ growth of gold nanoparticles on the surface of WS2 nanosheets. The defects of prepared Au-WS2 nanocomposites may accelerate electron transfer and facilitate the absorption of dissolved oxygen. As a result, Au-WS2 nanocomposites-enhanced electrochemiluminescence (ECL) is observed for the first time, and is further used to fabricate a non-destructive and label-free analytical interface. The ECL interface can selectively detect DA in a range of 5.0 nM-200 mu M with a detection limit of 3.23 nM. Meanwhile, since the architecture on the ECL interface is not destroyed during the detection procedure, DA can be quantified continuously at least six times after one fabrication. In addition, the proposed ECL interface can accurately monitor the release of DA from PC12 cells manipulated by K+ and nifidipine, indicating great potential of this ECL sensor for surveying DA-related investigations.
文章鏈接：
https://www.sciencedirect.com/science/article/pii/S0925400519301157?via%3Dihub
版權(quán)與免責(zé)聲明：本網(wǎng)頁的內(nèi)容由收集互聯(lián)網(wǎng)上公開發(fā)布的信息整理獲得。目的在于傳遞信息及分享，并不意味著贊同其觀點(diǎn)或證實(shí)其真實(shí)性，也不構(gòu)成其他建議。僅提供交流平臺(tái)，不為其版權(quán)負(fù)責(zé)。如涉及侵權(quán)，請(qǐng)聯(lián)系我們及時(shí)修改或刪除。郵箱：sales@allpeptide.com