戴志暉教授課題組在ACS APPLIED MATERIALS & INTERFACES發(fā)表研究論文
Mild Hyperthermia-Enhanced Enzyme-Mediated Tumor Cell Chemodynamic Therapy
Liu, XH (Liu, Xinhe)[ 1,2 ] ; Liu, Y (Liu, Ying)[ 1,2 ] ; Wang, JN (Wang, Junning)[ 1,2 ] ; Wei, TX (Wei, Tianxiang)[ 1,2,3 ]*; Dai, ZH (Dai, Zhihui)[ 1,2,4 ]*（戴志暉）
[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Nanjing Normal Univ, Jiangsu Key Lab Biofunct Mat, Sch Chem & Mat Sci, Nanjing 210023, Jiangsu, Peoples R China
[ 3 ] Nanjing Normal Univ, Sch Environm, Nanjing 210023, Jiangsu, Peoples R China
[ 4 ] Nanjing Normal Univ, Ctr Anal & Testing, Nanjing 210023, Jiangsu, Peoples R China
ACS APPLIED MATERIALS & INTERFACES，201907,11(26),23065-23071
The heterogeneity and diversity of tumors seriously attenuate the curative outcome of single treatment modes. Combined therapy has been demonstrated to be a promising candidate to enhance therapeutic efficacy compared with monotherapy. As an emerging therapeutic strategy, chemodynamic therapy (CDT) has drawn extensive attention in recent years. However, the therapeutic efficiency of CDT is still unsatisfying because the level of intracellular hydrogen peroxide (H2O2) restricts the production of hydroxyl radicals ((OH)-O-center dot). In this study, a novel curative strategy which combines glucose oxidase (GOx)-mediated Fe3O4-based Fenton reaction and multiwalled carbon nanotube (MWNT)-produced mild hyperthermia enhancer is proposed, achieving a Mild hyperthermia-enhanced enzyme-mediated tumor cell CDT. GOx can catalyze the conversion of glucose into gluconic acid and H2O2, which can elevate acidity in the tumor microenvironment and boost Fe3O4-based Fenton reaction, producing a myriad of (OH)-O-center dot to induce tumor cell death. Furthermore, by using the theory that a temperature rise expedites the kinetics of a chemical reaction, producing a higher reaction rate and more resultants per unit time, we integrate MWNTs in this therapy system, which generate mild hyperthermia so as to accelerate the Fenton reaction for increasing the productivity of (OH)-O-center dot. Therefore, an amplified CDT can be realized. The therapy platform, mild hyperthermia-enhanced GOx-mediated CDT, provides an effective treatment for cancer and takes CDT a step further.
文章鏈接：
https://pubs.acs.org/doi/10.1021/acsami.9b08257
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