萬密密副教授毛春教授課題組在JOURNAL OF MATERIALS CHEMISTRY B發(fā)表研究論文
Novel heparin-loaded mesoporous tubular micromotors formed via template-assisted electrochemical deposition
Wang, Q (Wang, Qi)[ 1 ] ; Wang, Y (Wang, Yan)[ 1 ] ; Guo, BY (Guo, Baoyan)[ 1 ] ; Shao, SB (Shao, Shuibin)[ 1 ] ; Yu, YQ (Yu, Yueqi)[ 1 ] ; Zhu, XT (Zhu, Xiaotan)[ 1 ] ; Wan, MM (Wan, Mimi)[ 1 ]*（萬密密）; Zhao, B (Zhao, Bo)[ 1 ] ; Bo, C (Bo, Chi)[ 2 ] ; Mao, C (Mao, Chun)[ 1 ] *（毛春）
[ 1 ] Nanjing Normal Univ, Natl & Local Joint Engn Res Ctr Biomed Funct Mat, Sch Chem & Mat Sci, Nanjing 210023, Jiangsu, Peoples R China
[ 2 ] Nanjing Tech Univ, State Key Lab Mat Oriented Chem Engn, Coll Food Sci & Light Ind, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Jiangsu, Peoples R China
JOURNAL OF MATERIALS CHEMISTRY B，201904,7(16),2688-2695
Based on the concept of the active drug delivery of micro- and nanomotors and the longer cycle time in the blood for drug-loaded tubular particles, it is important to develop novel tubular micromotors that could increase drug loading and achieve more effective treatments in the biomedical field. Here, a novel kind of mesoporous tubular micromotor used to load heparin (Hep) and formed via template-assisted electrochemical deposition is presented. Firstly, the mesoporous tubular micromotors were composed of poly(3,4-ethylenedioxythiophene) (PEDOT), mesoporous silica (MS) and manganese dioxide (MnO2), and were simply fabricated via template-assisted electrochemical growth. Then, the drug Hep was loaded into PEDOT/MS/MnO2 via a simple soaking process. Finally, the release process, cytotoxicity, and blood compatibility tests and motion study for these mesoporous tubular micromotors of PEDOT/MS/MnO2-Hep were performed. Results indicated that the micromotors we prepared showed good controlled release of Hep, anticoagulant effects, non-cytotoxicity and autonomous motion ability. The new drug carrier and motion mode will give rise to more potential applications of Hep in the biomedical field.
文章鏈接：
https://pubs.rsc.org/en/content/articlelanding/2019/TB/C9TB00131J#!divAbstract
版權(quán)與免責(zé)聲明：本網(wǎng)頁的內(nèi)容由收集互聯(lián)網(wǎng)上公開發(fā)布的信息整理獲得。目的在于傳遞信息及分享，并不意味著贊同其觀點(diǎn)或證實(shí)其真實(shí)性，也不構(gòu)成其他建議。僅提供交流平臺(tái)，不為其版權(quán)負(fù)責(zé)。如涉及侵權(quán)，請(qǐng)聯(lián)系我們及時(shí)修改或刪除。郵箱：sales@allpeptide.com