劉平副教授、孫培培教授課題組在JOURNAL OF ORGANIC CHEMISTRY發(fā)表研究論文
An Approach to Quinoline-Fused Imidazopyridines via CDC of Ethers with Imidazopyridines under Metal-Free Conditions
Lian, GF (Lian, Guifang)[ 1 ] ; Li, JY (Li, Jingyu)[ 1 ] ; Liu, P (Liu, Ping)[ 1 ]*（劉平） ; Sun, PP (Sun, Peipei)[ 1 ]*（孫培培）
[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Sch Chem & Mat Sci, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Nanjing 210023, Jiangsu, Peoples R China
JOURNAL OF ORGANIC CHEMISTRY，201912,84(24),16346-16354
An NH4I-catalyzed cross-dehydrogenative coupling (CDC) reaction of ethers with imidazopyridine cascade cyclization under transition-metal-free conditions has been developed. Cheap, commercially available ethers were used as both reagents and solvents, and green aqueous H2O2 was used as an oxidizing agent. A series of substituents on 2-(2-aminoaryl) imidazo[1,2-a]pyridines were tolerated, and the reaction gave quinoline-fused imidazopyridines in moderate to good yields.
文章鏈接：
https://pubs.acs.org/doi/10.1021/acs.joc.9b02897
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