劉平副教授、孫培培教授課題組在ANGEWANDTE CHEMIE-INTERNATIONAL EDITION發(fā)表研究論文
Electrochemical Difunctionalization of Alkenes by a Four-Component Reaction Cascade Mumm Rearrangement: Rapid Access to Functionalized Imides
Zhang, XF (Zhang, Xiaofeng)[ 1 ] ; Cui, T (Cui, Ting)[ 1 ] ; Zhao, X (Zhao, Xin)[ 1 ] ; Liu, P (Liu, Ping)[ 1 ]*（劉平）; Sun, PP (Sun, Peipei)[ 1 ]*（孫培培）
[ 1 ] Nanjing Normal Univ, Jiangsu Collaborat Innovat Ctr Biomed Funct Mat, Jiangsu Prov Key Lab Mat Cycle Proc & Pollut Cont, Sch Chem & Mat Sci, Nanjing 210023, Peoples R China
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION，202002,59(9),3465-3469
An electrochemical four-component reaction cascade Mumm rearrangement was developed. It is a rare example of in situ generation of O-acyl isoamides for 1,3-(O -> N) acyl transfer. Inexpensive, commercially available arylethylenes, aryl or heterocyclic acids, acetonitrile, and alcohols were used as substrates. A wide range of aryl acids and alcohols were tolerated and provided imides in satisfactory yields. Subsequent hydrolysis of imides could be utilized to synthesize valuable amides and beta-amino alcohol derivatives.
文章鏈接：
https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201913332
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