戴志暉教授課題組在ANALYST發(fā)表研究論文
Colloidal-sized zirconium porphyrin metal-organic frameworks with improved peroxidase-mimicking catalytic activity, stability and dispersity
Wang, JN (Wang, Junning)[ 1 ] ; Wei, TX (Wei, Tianxiang)[ 2 ] ; Liu, YC (Liu, Yichen)[ 1 ] ; Bao, MY (Bao, Mengyuan)[ 1 ] ; Feng, R (Feng, Rui)[ 1 ] ; Qian, YX (Qian, Yuxuan)[ 1 ] ; Yang, X (Yang, Xue)[ 1 ] ; Si, L (Si, Ling)[ 1 ]*（司玲）; Dai, ZH (Dai, Zhihui)[ 1 ]*（戴志暉）
[ 1 ] Nanjing Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Biofunct Mat, Nanjing 210023, Peoples R China
[ 2 ] Nanjing Normal Univ, Sch Environm, Nanjing 210023, Peoples R China
ANALYST，202004,145(8),3002-3008
Metal-organic frameworks (MOFs) have attracted great attention as enzyme mimic materials in colorimetric hydrogen peroxide (H2O2) detection. At present, it is highly desirable but remains challenging to prepare MOFs with high stability and dispersity to further improve their peroxidase-mimicking catalytic activity. In this work, we developed a new and facile method for the synthesis of a sub-100 nm peroxidase-mimicking zirconium porphyrin metal-organic framework (Zr-PorMOF) via a solvothermal method. The experimental results indicated that compared with the micron-sized crystals obtained using a classical synthesis method, the catalytic activity, stability and dispersity in water of the colloidal Zr-PorMOF were obviously enhanced. The as-synthesized colloidal Zr-PorMOF was further successfully applied in colorimetric H2O2 detection, and satisfactory detection performance was obtained. Furthermore, the colloidal Zr-PorMOF was also successfully employed in the construction of a peroxidase-based tandem catalysis system. Taking glucose oxidase as an example, this system was successfully applied for glucose sensing in real human serum samples, which proved its practical feasibility in diabetes diagnosis and indicates its high potential feasibility in peroxidase-related applications in complex biomatrix.
文章鏈接：
https://pubs.rsc.org/en/content/articlelanding/2020/AN/C9AN02418B#!divAbstract
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