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時(shí)間：4月19日上午10:00?

地點(diǎn)：藥學(xué)院224

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Abstract:

Malaria parasites are exquisitely adapted for survival within human red blood cells. Understanding how malaria parasites enter red blood cells is essential for developing strategies to stop blood stage infection. An important feature of Plasmodium?invasion is the host cell selectivity that the different species have for cells of the erythroid lineage. Indeed, Plasmodium vivax?preferentially invades reticulocytes which are young red blood cells. Several members of P. vivax?Reticulocyte Binding Protein (PvRBP) family bind specifically to reticulocytes suggesting that they play a crucial role in restricted host cell selectivity. We report the first crystal structures of the erythrocyte-binding domain from the PvRBP family and present our findings on the a new entry receptor that allows Plasmodium vivax?to invade the youngest human red blood cells.

Biosketch:

Dr. Wai-Hong Thamobtained her Ph.D from Princeton University and is a group leader at the Walter and Eliza Hall Institute since 2013. Her research focuses on the discovery of new host-pathogen interactions that govern successful malaria infection. She studies P. falciparum?and P. vivax?parasite adhesins that are required for entry into red blood cells as well as merozoite surface proteins that bind to human complement proteins. Her lab combines molecular, cellular and structural biology methods to study the mechanisms of parasite invasion and complement evasion strategies of malaria parasites. The overarching aim is to rationally design and generate new inhibitors or antibodies that are able to block these interactions and hence, stop the recurrent infection in the host.

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